Pseudomonas aeruginosa is an opportunistic pathogen that infects burns, wounds, surgical incisions and sites of catheterization. It is the most common cause of infections of burn injuries and of the outer ear (otitis externa) . It can, in rare circumstances, cause community-acquired pneumonias, as well as ventilator-associated pneumonias.
P. aeruginosahas has immense potential to develop resistance against antibiotic as is evident from the fact that its genome contains the largest known resistance island with more than 50 resistance genes ( Wikipedia ). This is an "antibiotic paradox" because the very first antibiotic to be discovered in the modern world, was pyocyanase , discovered in 1888 by E. de Freudenreich. It was a mixture of several antibacterially active substances: pyocyanin, 1-hydroxyphenazine and an oily fraction. This natural antibiotic was able to kill typhoid , diphtheria and plague bacteria .
Pyocyanase has been produced commercially, but unfortunately it was unstable and toxic. (pyocyanin and 1-hydroxyphenazine are also antifungal agents active against Candida albicans and Aspergillus fumigatus ; Kerr J R et al. , 1999 ).
β proteobacteria: P. acidovorans , P. alliicola , P. antimicrobica , P. avenae , P. butanovorae , P. caryophylli , P. cattleyae , P. cepacia , P. cocovenenans , P. delafieldii , P. facilis , P. flava , P. gladioli , P. glathei , P. glumae , P. graminis , P. huttiensis , P. indigofera , P. lanceolata , P. lemoignei , P. mallei , P. mephitica , P. mixta , P. palleronii , P. phenazinium , P. pickettii , P. plantarii , P. pseudoflava , P. pseudomallei , P. pyrrocinia , P. rubrilineans , P. rubrisubalbicans , P. saccharophila , P. solanacearum , P. spinosa , P. syzygii , P. taeniospiralis , P. terrigena , P. testosteroni .
Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America
Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha , American Medical Association , Oklahoma State Medical Association , Southern Society for Clinical Investigation , Association of Professors of Medicine , American College of Physicians , Infectious Diseases Society of America
Disclosure: Nothing to disclose.